What is a common side effect associated with tricyclic antidepressants?

Tricyclic antidepressants (TCAs) are known to have a range of side effects due to their action on various neurotransmitter systems and their interaction with histaminergic, adrenergic, and muscarinic receptors. One of the most common side effects associated with TCAs is dry mouth, which occurs due to the anticholinergic effects of these medications. They block the action of acetylcholine on muscarinic receptors, which can lead to reduced saliva production and a sensation of dryness in the mouth.

This side effect is significant as it can affect patients' comfort and oral health. Maintaining hydration and oral hygiene becomes important for individuals experiencing dry mouth. Understanding this side effect can help healthcare providers manage and mitigate the discomfort associated with tricyclic antidepressant therapy.